RUSH for G6PD!

Molecular analysis of three novel G6PD variants: G6PD Pedoplis-Ckaro, G6PD Piotrkow and G6PD Krakow.

We present three novel mutations in the G6PD gene and discuss the changes they cause in the 3-dimensional structure of the enzyme: 573C-->G substitution that predicts Phe to Leu at position 191 in the C-terminus of helix alphae, 851T-->C mutation which results in the substitution 284Val--> -->Ala in the beta+alpha domain close to the C-terminal part of helix alphaj, and 1175T-->C substitution t...

G6PD deficiency.

T HIRTY-FIVE YEARS ago Dr William Dameshek, the first editor of the emerging journal Blood, invited me to write a review on “The Hemolytic Effect of Primaquine.”’ At the time, primaquine sensitivity, which had just recently been shown to be caused by a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD); represented a unique example of an inherited deficiency of an enzyme that cau...

Still too early for the gold rush.

Benjamin Rush on cancer.

It is f i t t ing in this b icentennial year of the United States, for the ed i f i ca t ion of oncologists, to cast a glance at what physicians o f the American Revolut ion though t and practiced about cancer . There is no better source of such en l igh tenment than the wri t ings o f Benjamin Rush (1745-1813) of Phi ladelphia. Of English Quaker stock, born in Pennsylvania and educated at Pr i...

Introduction Penelope Rush

This book is a collection of new essays around the broad central theme of the nature of logic, or the question: ‘what is logic?’ It is a book about logic and philosophy equally. What makes it unusual as a book about logic is that its central focus is on metaphysical rather than epistemological or methodological concerns. By comparison, the question of the metaphysical status of mathematics and ...